Product Research and Development

Nanovis’ broad portfolio of nanotechnologies gives our scientists many ways to enhance surgical implants and biomaterials.  Nanovis’ technology includes nanopatterned surfaces on implant metals, polymers, ceramics and ceramic composites as well as bone growth peptides, carbon nanofibers and self assembling nanomaterials.

Nanovis' interests are in reducing implant complications related to stability and bacteria colonization. While our technologies are helpful across the spectrum of orthopedics, Nanovis is focusing our development efforts to launch differentiated implants in the $10 billion(+) spinal implant market.

NANOPATTERNED IMPLANT SURFACES
While the surface of our bone and soft tissues are rough at a nanoscale, today's implants are smooth at a nanoscale. This mismatch between implant and patient is believed to have the potential to adversely impact healing times.

To help illustrate the dramatic difference between the nano surface of current implants and nano surface of bone, consider which of the scanning electron micrographs below is actually of bone?

 

Answer: A - titanium, B - poly-ether-ether-ketone, C - bone, D - Nanovis' nano surfaced poly-ether- ether ketone, E - Nanovis' nano surfaced titanium

Nanovis’ scientists have invented a wide range of nanosurfaces intended to increase tissue to implant bone on growth on a wide range of implant materials from titanium to polypropylene to polyetheretherketone (PEEK). The nanosurfaces have increased markers for bone on growth on a wide range of materials in vitro as noted in the example below for our nanosurfaced titanium alloy.

In three successful short and long term in vivo pilots Nanovis observed trends toward increased bone on growth on our nano surfaced titanium alloy compared to conventional titanium alloy. The histology images below capture the increase in bone on growth on a nano surfaced Nanovis titanium bone screw compared to a conventional bone screw 28 days after implantation.

Nanovis’ is commercializing implants that use this nanotechnology across a range of titanium and PEEK spine implants.

Nanostructured Biomaterial Platform

Nanovis nanostructured biomaterials are designed to act as highly effective tissue scaffolds with customizable resorption profiles and capability for localized drug delivery. Nanovis uses the tissue integration and inflammation reduction properties of nanomaterials to develop biomaterial products with important advantages over conventional biomaterials. Nanovis is currently developing nanostructured biomaterials using novel nanostructured polymers and nanoscale ceramics as well as novel self assembling nanomaterials such as the helical rosette nanotubes shown on the right.

 

 

Bone Growth Peptide Platform

Nanovis has acquired and is developing an important set of bone growth peptides. These peptides are suitable for delivery as a combination product with our nanostructured biomaterials and are designed to provide a complementary mechanism of action. Nanovis is pursuing nanostructured biomaterial/bone growth peptide programs primarily in the orthopedic fields. Early work with adhesion peptides is shown in the graphic below.

Increased osteoblast growth in the presence of KRSR functionalized on HNPs (hydroxyapatite nanoparticles) compared to corresponding conventional HP (hydroxyapatite, or micron, particles).

Taken together, Nanovis’ innovative nanostructured biomaterials and bone growth peptides provide an important set of products for Nanovis’ orthopedic strategy.
Nanovis Nanosurface intellectual property, expertise and experience covers a wide array of polymer, metal and ceramic implant materials. Nanovis, frequently in collaboration with strategic partnerships is developing implant nanosurfaces to improve the clinical outcomes for dental, orthopedic, soft tissue repair, urogenital, cardiovascular and neurosurgical implants.

 

 

If you are a medical professional and would like updates on future technology developments and product launches at Nanovis, please send us your contact information.